CHIR 98014
SIGMA/SML1094 - ≥98% (HPLC)
Synonym: N-6-
CAS Number: 252935-94-7
Empirical Formula (Hill Notation): C20H17Cl2N9O2
Molecular Weight: 486.31
MDL Number: MFCD10565922
Linear Formula: C20H17Cl2N9O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to brown |
| form | powder |
| InChI | 1S/C20H17Cl2N9O2/c21-12-1 |
| InChI key | MDZCSIDIPDZWKL-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | NC1=C(C=CC(NCCNC2=NC(C3=C |
| solubility | DMSO: 0.5 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Application: | CHIR 98014 has been used for the generation of small molecules neural progenitor cells and differentiation towards motor neurons. It has also been used as a Wnt/β-catenin pharmacological agonist in the cell-conditioned medium to perform chromatin immunoprecipitation (ChIP) studies in HT22 neurons. |
| Biochem/physiol Actions: | CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK3α and GSK3β, respectively. CHIR98014 is 500-fold to >10,000-fold selectivity for GSK-3 versus 20 other protein kinases tested, including closest homologs Cdc2 and ERK2. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |