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Roflumilast

SIGMA/SML1099 - ≥98% (HPLC)

Synonym: 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide

CAS Number: 162401-32-3
Empirical Formula (Hill Notation): C17H14Cl2F2N2O3
Molecular Weight: 403.21
MDL Number: MFCD00938270
Linear Formula: C17H14Cl2F2N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1099-10MG 10 mg
 $73.60
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45-SML1099-50MG 50 mg
 $297.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChI key MNDBXUUTURYVHR-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Application: Roflumilast has been used to evaluate its effect on acute lung inflammation and chronic lung changes in models of cigarette exposure in mice. It is also used to investigate its therapeutic potential to ameliorate primary blast-induced deficits in long-term potentiation (LTP).
Biochem/physiol Actions: Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 0.8 nM. Roflumilast has anti-inflammatory properties and is used clinically to treat COPD.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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