Varespladib
SIGMA/SML1100 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 172732-68-2
Empirical Formula (Hill Notation): C21H20N2O5
Molecular Weight: 380.39
Linear Formula: C21H20N2O5
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C21H20N2O5.Na/c1-2-14- |
| InChI key | XZZUHXILQXLTGV-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [Na+].[n]2(c3c(c(ccc3)OCC |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Varespladib has been used as a secretory phospholipase A (sPLA2) inhibitor: • to test its effect on the human astrocytes subjected to psychosine-induced toxicity • to test its neutralization functionality on the black snake species P. colletti venom • in combination with snake venom metalloproteinases (SVMP)-inhibitor, marimastat to test its protective functionality on envenoming by vipers |
| Biochem/physiol Actions: | Varespladib is a potent and selective inhibitor of secretory phospholipase A2 (sPLA2). |
| Biochem/physiol Actions: | Varespladib is a potent and selective inhibitor of secretory phospholipase A2 (sPLA2). The compound Varespladib inhibits both human and mouse sPLA2 group IIA, V, and X enzymes at low nM concentrations. |
| Biochem/physiol Actions: | Varespladib is effective against viper and elapid venoms and is used in snakebite therapy. It is reported to interact with the hydrophobic channel of the PLA2-like toxin in in vitro structural studies. It blocks inflammatory cascades related to the sPLA2. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 41106300 |