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Darifenacin hydrobromide

SIGMA/SML1102 - ≥98% (HPLC)

Synonym: (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide hydrobromide; UK 88525-04

CAS Number: 133099-07-7
Empirical Formula (Hill Notation): C28H30N2O2 · HBr
Molecular Weight: 507.46
MDL Number: MFCD08141803
Linear Formula: C28H30N2O2 · HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1102-10MG 10 mg
 $81.90
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45-SML1102-50MG 50 mg
 $335.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H30N2O2.BrH/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26;/h1-12,19,25H,13-18,20H2,(H2,29,31);1H/t25-;/m1./s1
InChI key UQAVIASOPREUIT-VQIWEWKSSA-N
optical activity [α]/D +41 to +49°, c = 1 in methylene chloride
Quality Level 100 
SMILES string O=C(N)C([C@H]1CN(CCC2=CC=C(OCC3)C3=C2)CC1)(C4=CC=CC=C4)C5=CC=CC=C5.Br
solubility DMSO: 20 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Application: Darifenacin hydrobromide has been used to inject experimental animals.
Biochem/physiol Actions: Darifenacin hydrobromide is an antispasmodic muscarinic antagonist, selective for blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. Darifenacin hydrobromide has 9 and 12-fold greater affinity for M3 compared to M1 and M5, respectively, and 59-fold greater affinity for M3 compared to both M2 and M4. Darifenacin is used clinically to treat urinary incontinence and overactive bladder syndrome.
Biochem/physiol Actions: Darifenacin hydrobromide is an antispasmodic muscarinic antagonist, selective for blocking the M3 muscarinic acetylcholine receptor.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Darifenacin is a muscarinic receptor antagonist. It is an extended release tablet that has 7.5 mg or 15 mg darifenacin as its hydrobromide salt.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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