STF-31
SIGMA/SML1108 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 724741-75-7
Empirical Formula (Hill Notation): C23H25N3O3S
Molecular Weight: 423.53
MDL Number: MFCD04153828
Linear Formula: C23H25N3O3S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C23H25N3O3S/c1-23(2,3) |
| InChI key | NGQPRVWTFNBUHA-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C(NC1=CN=CC=C1)C2=CC=C( |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | STF-31 has been used in glucose transporter 1 (GLUT1) inhibition. |
| Biochem/physiol Actions: | STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL. |
| Biochem/physiol Actions: | STF-31 selectively inhibits the glucose transporter GLUT1. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 46 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |