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KU-55933

SIGMA/SML1109 - ≥98% (HPLC)

Synonym: 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-Pyran-4-one; 2-(Morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one

CAS Number: 587871-26-9
Empirical Formula (Hill Notation): C21H17NO3S2
Molecular Weight: 395.49
MDL Number: MFCD08276985
Linear Formula: C21H17NO3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1109-5MG 5 mg
 $119.00
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45-SML1109-25MG 25 mg
 $460.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChI key XRKYMMUGXMWDAO-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Application: KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.
Biochem/physiol Actions: KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
Biochem/physiol Actions: KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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