Adaphostin
SIGMA/SML1110 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 241127-58-2
Empirical Formula (Hill Notation): C24H27NO4
Molecular Weight: 393.48
MDL Number: MFCD06411386
Linear Formula: C24H27NO4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C24H27NO4/c26-21-5-6-2 |
InChI key | YJZSUCFGHXQWDM-ONHXBKDTSA |
Quality Level | 100 |
SMILES string | O=C(C1=CC=C(NCC2=CC(O)=CC |
solubility | DMSO: 20 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Adaphostin is a p210bcr/abl tyrosine kinase inhibitor displaying anti-proliferative activity in leukemia models, human prostate cancer cell line PC-3 and other cancer cell lines. Adaphostin is a potent inducer of myeloid cell death. Similarly to AG957, adaphostin appears to induce a degradation of WT and mutated Bcr/Abl. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |