RSC133

SIGMA/SML1113 - ≥98% (HPLC)

Synonym: 3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide; RSC 133; Reprogramming stimulating compound 133

CAS Number: 1418131-46-0
Empirical Formula (Hill Notation): C₁₈H₁₅N₃O₂
Molecular Weight: 305.33
Linear Formula: C₁₈H₁₅N₃O₂
Product Type: Chemical

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C18H15N3O2/c19-18(23)12-4-3-5-14(10-12)21-17(22)9-8-13-11-20-16-7-2-1-6-15(13)16/h1-11,20H,(H2,19,23)(H,21,22)/b9-8+
InChI key	HYUDSQGICKAEGE-CMDGGOBGSA-N
Quality Level	100
SMILES string	NC(C1=CC=CC(NC(/C=C/C2=CNC3=C2C=CC=C3)=O)=C1)=O
solubility	DMSO: 20 mg/mL, clear
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:	RSC133 is an epigenetic modulator that effectively enhances reprogramming of human somatic cells and maintenance of human stem cell pluripotency. Apparently, RSC133 facilitates the reprograming by dual inhibition of histone deacetylase and DNA methyltransferase activities. In hFFs, RSC133 rapidly activates pluripotency-associated genes Nanog, Oct4, and Rex1 up to 2- to 2.5-fold. RSC133 exerts positive effects on cell proliferation and ablates pro-senescence phenotypes.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes:	Light sensitive
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn,N
Risk Statements	22-51/53
Safety Statements	61
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable