Synonym: N-(6-Methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
CAS Number: 686772-17-8
Empirical Formula (Hill Notation): C23H20N4O3S3
Molecular Weight: 496.62
Linear Formula: C23H20N4O3S3
Product Type: Chemical
assay |
≥95% (HPLC) |
color |
white to light brown |
form |
powder |
InChI |
1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28) |
InChI key |
RHUJMHOIQBDFQR-UHFFFAOYSA-N |
Quality Level |
100 |
SMILES string |
O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5 |
solubility |
DMSO: 0.5 mg/mL, clear (warmed) |
storage temp. |
−20°C |
Biochem/physiol Actions: |
IWP-4 blocks Wnt family member 5a. It blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways. |
Biochem/physiol Actions: |
IWP-4 is a potent inhbitor of the Wnt pathway regulatory protein porupine (Porcn). IWP-4 blocks palmitylation, and subsquent secretion and activity of Wnt. IWP-4 induces the differentiation of human pluripotent stem cells into cardiomyocytes. |
Packaging: |
5, 25 mg in glass bottle |
Symbol |
GHS07 |
Signal word |
Warning |
Hazard statements |
H302 |
Hazard Codes |
Xn |
Risk Statements |
22 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥95% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |