ML345

SIGMA/SML1117 - ≥98% (HPLC)

Synonym: 5-Fluoro-2-[5-(morpholine-4-sulfonyl)-2-morpholin-4-yl-phenyl]-benzo[d]isothiazol-3-one; CID 57390068

Empirical Formula (Hill Notation): C₂₁H₂₂FN₃O₅S₂
Molecular Weight: 479.54
Linear Formula: C₂₁H₂₂FN₃O₅S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1117-5MG	5 mg	$149.00 1/EA		Add To Favorites
45-SML1117-25MG	25 mg	$475.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C21H22FN3O5S2/c22-15-1-4-20-17(13-15)21(26)25(31-20)19-14-16(32(27,28)24-7-11-30-12-8-24)2-3-18(19)23-5-9-29-10-6-23/h1-4,13-14H,5-12H2
InChI key	FVKOFZKSMMIUTL-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=S(C1=CC(N(C2=O)SC3=C2C=C(F)C=C3)=C(N4CCOCC4)C=C1)(N5CCOCC5)=O
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:	ML345 has effective concentration (EC50) value of 188 nM.
Biochem/physiol Actions:	ML345 is a cell penetrant, potent and moderately selective insulin degrading enzyme (IDE) inhibitor that targets Cys819 in IDE. IDE is involved in β-chain of insulin degradation and linked to β-amyloid degradation. Recent findings indicate that IDE inhibition is a valid strategy for diabetes mellitus type 2 (DMT2) treatment.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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