Synonym: (2S,4R,4aR,4bR,6aS,12bS,12cS,14aS)- 3,4,4a,4b,5,6,6a,7,12,12b,12c,13,14,14a-tetradecahydro-4-hydroxy-α,α,4a,12b,12c-pentamethyl-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]isobenzofuro[5,6-e]indole-2-methanol; 1′α-Hydroxy-paspaline; FO 2546L
CAS Number: 167427-23-8
Empirical Formula (Hill Notation): C28H39NO3
Molecular Weight: 437.61
Linear Formula: C28H39NO3
Product Type: Chemical
assay |
≥95% (HPLC) |
biological source |
Albophoma yamanashiensis |
color |
white to beige |
form |
powder |
InChI |
1S/C28H39NO3/c1-25(2,31)23-15-21(30)27(4)20-11-10-16-14-18-17-8-6-7-9-19(17)29-24(18)28(16,5)26(20,3)13-12-22(27)32-23/h6-9,16,20-23,29-31H,10-15H2,1-5H3/t16-,20?,21+,22-,23-,26-,27+,28+/m0/s1 |
InChI key |
SVYIMXYKHRBHSG-CDIJYFRTSA-N |
Quality Level |
100 |
SMILES string |
OC(C)(C)[C@H]1O[C@@]2([H])CC[C@]3(C)[C@]4(C)[C@@](CC5=C4NC6=C5C=CC=C6)([H])CCC3[C@]2(C)[C@H](O)C1 |
solubility |
DMSO: 10 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Terpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of human Eg5. Studies indicate that Terpendole E inhibits Eg5 mutants resistant to S-trityl-L-cysteine and other Eg5 inhibitors. Also, Terpendole E is an ACAT (Acyl-CoA:cholesterol acyltransferase) inhibitor. |
Packaging: |
1 mg in glass bottle |
Packaging: |
250 μg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥95% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |