Pep2-8 trifluoroacetate salt
SIGMA/SML1132 - ≥95% (HPLC), powder
Synonym: Ac-TVFTSWEEYLDWV-NH2 trifluoroacetate salt; Ac-
Empirical Formula (Hill Notation): C83H110N16O24 · xC2HF3O2
Molecular Weight: 1715.85 (free base basis)
Linear Formula: C83H110N16O24 · xC2HF3O2
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| color | colorless to pale yellow |
| form | powder |
| Quality Level | 100  |
| shipped in | wet ice |
| storage temp. | −20°C |
| Amino Acid Sequence: | Ac-Thr-Val-Phe-Thr-Ser-Tr |
| Biochem/physiol Actions: | Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells. |
| Biochem/physiol Actions: | Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor. |
| Biochem/physiol Actions: | Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A), serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding. It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site. |
| Packaging: | 1 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |