SGC-CBP30
SIGMA/SML1133 - ≥98% (HPLC)
Synonym: 2-
Empirical Formula (Hill Notation): C28H33ClN4O3
Molecular Weight: 509.04
Linear Formula: C28H33ClN4O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C28H33ClN4O3/c1-18(32- |
InChI key | GEPYBHCJBORHCE-SFHVURJKSA |
Quality Level | 100 |
SMILES string | CC1=C(C(C)=NO1)C2=CC=C3C( |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Application: | SGC-CBP30 has been used in immunofluorescence, to study the regulation of HAT (histone acetyltransferase) activity. It has also been used to abolish synergistic gene expression induced by transcription factors in hepatocytes. |
Biochem/physiol Actions: | SGC-CBP30 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.021 and 0.038 μM, respectively). SGC-CBP30 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please visit the SGC-CBP30 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
Biochem/physiol Actions: | SGC-CBP30 might serve as a therapeutic agent in treating cancer. In ankylosing spondylitis and psoriatic arthritis condition, SGC-CBP30 is found to decrease immune cell production of T helper cell 17 and other pro-inflammatory cytokines. |
Features and Benefits: | SGC-CBP30 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC . |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Other Notes: | SGC-CBP30 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC-CBP30 probe summary on the Chemical Probes Portal website. |
Packaging: | 5, 25 mg in glass bottle |
Hazard statements | H413 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |