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MG-132(R)

SIGMA/SML1135 - ≥95% (HPLC)

Synonym: Z-L-Leu-D-Leu-L-Leu-al

CAS Number: 1211877-36-9
Empirical Formula (Hill Notation): C26H41N3O5
Molecular Weight: 475.62
MDL Number: MFCD28580122
Linear Formula: C26H41N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1135-5MG 5 mg
 $532.00
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assay ≥95% (HPLC)
form powder
InChI 1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
InChI key TZYWCYJVHRLUCT-ZRBLBEILSA-N
product line SAFC Hitech®
Quality Level 200 
SMILES string O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O
solubility DMSO: soluble
storage temp. −20°C
Biochem/physiol Actions: MG-132(R) is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells at 10 M. MG-132(R) blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. However, MG-132(R) also activates c-Jun N-terminal protein kinase (JNK-1), which initiates apoptosis in response to cell stress. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types.
Legal Information: SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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