SW155246

SIGMA/SML1136 - ≥98% (HPLC)

Synonym: 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide

CAS Number: 420092-79-1
Empirical Formula (Hill Notation): C₁₆H₁₁ClN₂O₅S
Molecular Weight: 378.79
Linear Formula: C₁₆H₁₁ClN₂O₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1136-5MG	5 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites
45-SML1136-25MG	25 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H
InChI key	JDYDEJYIVZNWQU-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC1=CC=C(NS(=O)(C2=CC=C(Cl)C([N+]([O-])=O)=C2)=O)C3=C1C=CC=C3
solubility	DMSO: 10 mg/mL, clear
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:	SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor that demethylates cytosines in vivo in a cell-based assay without affecting protein levels or generating reactive oxygen species. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes:	light sensitive
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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