Rostafuroxin

SIGMA/SML1139 - ≥98% (HPLC)

Synonym: (3,5,14)-21,23-epoxy24-Norchola-20,22-diene-3,14,17-triol; PST 2238

CAS Number: 156722-18-8
Empirical Formula (Hill Notation): C₂₃H₃₄O₄
Molecular Weight: 374.51
Linear Formula: C₂₃H₃₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1139-5MG	5 mg	$164.00 1/EA	Add To Favorites
45-SML1139-25MG	25 mg	$445.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
InChI key	AEAPORIZZWBIEX-DTBDINHYSA-N
Quality Level	100
SMILES string	[o]1cc(cc1)[C@@]2([C@@]3([C@@]([C@H]4[C@@H]([C@@]5([C@@H](C[C@H](CC5)O)CC4)C)CC3)(CC2)O)C)O
solubility	DMSO: 20 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Rostafuroxin is a derivative of digitoxigenin. It protects animal models against podocyte lesions and proteinuria by counteracting mutant β-adducin and ouabain-mediated effects.
Biochem/physiol Actions:	Rostafuroxin is a digitoxygenin derivative that selectively antagonizes the effects of endogenous ouabain on the Na⁺,K⁺-ATPase, which maintains sodium and potassium ion gradients across plasma membranes. Rostafuroxin lowers blood pressure (BP) in animal models of hypertension.
Biochem/physiol Actions:	Rostafuroxin is a Na-K ATPase; Ouabain antagonist.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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