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VU0071063

SIGMA/SML1142 - ≥98% (HPLC)

Synonym: 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

CAS Number: 333415-38-6
Empirical Formula (Hill Notation): C18H22N4O2
Molecular Weight: 326.39
MDL Number: MFCD02648040
Linear Formula: C18H22N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1142-25MG 25 mg
 $446.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
InChI key ZFZAIHKQJBMYLO-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC50 = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.
Biochem/physiol Actions: VU0071063 is a specific activator of SUR1-containing KATP channels.
Biochem/physiol Actions: VU0071063 is also known as [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. It serves as a major compound for examining β-cell physiology, KATP channel gating and a new chemical scaffold for evolving enhanced activators with medicinal chemistry.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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