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PTC-209

SIGMA/SML1143 - ≥98% (HPLC)

Synonym: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

CAS Number: 315704-66-6
Empirical Formula (Hill Notation): C17H13Br2N5OS
Molecular Weight: 495.19
MDL Number: MFCD02110649
Linear Formula: C17H13Br2N5OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1143-5MG 5 mg
 $129.00
1/EA		 Add To Favorites
45-SML1143-25MG 25 mg
 $525.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to brown
form powder
InChI 1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H,1-2H3,(H,22,23)
InChI key XVOOCQSWCCRVDY-UHFFFAOYSA-N
Quality Level 100 
SMILES string BrC1=CC(OC)=CC(Br)=C1NC2=NC(C3=C(C)N=C4N3C=CC=N4)=CS2
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: PTC-209 has been used as a B lymphoma Mo-MLV insertion region 1 homolog (BMI1) inhibitor to study its effects on:
• the cell viability of canine osteosarcoma (OSA) cell lines
• lipidated microtubule-associated protein 1 light chain 3 (LC3B-II) and Sequestosome 1 (SQSTM1) protein levels in ovarian cancer (OvCa) cells
• cardiac reprogramming efficiency in mouse embryonic fibroblasts (MEF)
Biochem/physiol Actions: PTC-209 inhibits the expression of the oncogene BMI-1 (B lymphoma Mo-MLV insertion region 1 homolog), which encodes a polycomb group RING finger protein involved in cell cycle. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs) The compound inhibits tumor growth, and reduces the levels of CICs present in colon cancer tumor xenografts in mice.
Biochem/physiol Actions: PTC-209 inhibits the expression of the oncogene BMI-1 (B lymphoma Mo-MLV insertion region 1 homolog).
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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