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YIL-781 hydrochloride

SIGMA/SML1148 - ≥98% (HPLC)

Synonym: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

CAS Number: 875258-85-8 (free base)
Empirical Formula (Hill Notation): C24H28FN3O2 · xHCl
Molecular Weight: 409.50 (free base basis)
MDL Number: MFCD19690924
Linear Formula: C24H28FN3O2 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1148-5MG 5 mg
 $149.00
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45-SML1148-25MG 25 mg
 $594.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color , white to yellow to light brown
form powder
InChI 1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
InChI key QQGRMONBDBMLSP-FERBBOLQSA-N
Quality Level 100 
SMILES string CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl
solubility H2O: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. room temp
Application: YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.
Biochem/physiol Actions: YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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