BMS-189453
SIGMA/SML1149 - ≥98% (HPLC)
Synonym: (E)
CAS Number: 166977-43-1
Empirical Formula (Hill Notation): C27H24O2
Molecular Weight: 380.48
MDL Number: MFCD18086870
Linear Formula: C27H24O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C27H24O2/c1-27(2)17-16 |
InChI key | VUODRPPTYLBGFM-CMDGGOBGSA |
Quality Level | 100 |
SMILES string | OC(C(C=C1)=CC=C1/C=C/C(C= |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | BMS-189453 is a potent RARβ agonist that acts as an antagonist against RARα and RARγ. BMS-189453 induces RARβ reporter gene expression at sub nanomolar levels, and is 30 fold more potent than all-trans retinoic acid for inducing TGFβ activity in normal breast cells. The compound BMS-189453 does not transactivate RARα or γ transcriptional activity, but binding to those family members induces a strong transrepression of phorbol ester-induced AP-1 activity (IC50 = 0.1 nM in HeLa and MCSF-7). BMS-189453 significantly increases the efficiency of cardiac differentiation of hESCs. |
Biochem/physiol Actions: | BMS-189453 specifically has sufficient bioavailability in rats and monkeys. BMS-189453 only binds to α, β, and γ retinoid receptors but its activation is unknown. BMS-189453 is found to inhibit the action of collagenase-3 (MMP-13) which catalyses cartilage matrix degradation. Thus, it serves to treat rheumatoid arthritis. |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |