(2S)-Hypusine dihydrochloride

SIGMA/SML1158 - ≥95% (HPLC)

Synonym: (+)-Hypusine dihydrochloride; N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride

Empirical Formula (Hill Notation): C₁₀H₂₃N₃O₃ · 2HCl
Molecular Weight: 306.23
Linear Formula: C₁₀H₂₃N₃O₃ · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1158-5MG	5 mg	$214.00 1/EA		Add To Favorites
45-SML1158-25MG	25 mg	$654.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to beige
form	powder
InChI	1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
InChI key	UTSZZUVUESAPQD-AHBBCRTASA-N
Quality Level	100
SMILES string	[H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
solubility	H₂O: 15 mg/mL, clear
storage condition	desiccated
storage temp.	−20°C

Biochem/physiol Actions:	(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.
Biochem/physiol Actions:	(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A).
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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