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(2S)-Hypusine dihydrochloride

SIGMA/SML1158 - ≥95% (HPLC)

Synonym: (+)-Hypusine dihydrochloride; N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride

Empirical Formula (Hill Notation): C10H23N3O3 · 2HCl
Molecular Weight: 306.23
Linear Formula: C10H23N3O3 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1158-5MG 5 mg
 $194.00
1/EA		 Add To Favorites
45-SML1158-25MG 25 mg
 $593.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
InChI key UTSZZUVUESAPQD-AHBBCRTASA-N
Quality Level 100 
SMILES string [H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
solubility H2O: 15 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: (2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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