CD40-TRAF6 signaling inhibitor

SIGMA/SML1160 - ≥98% (HPLC)

Synonym: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one; Compound 6877002

CAS Number: 433249-94-6
Empirical Formula (Hill Notation): C₁₇H₁₇NO
Molecular Weight: 251.32
Linear Formula: C₁₇H₁₇NO
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1160-5MG	5 mg	$120.00 1/EA		Add To Favorites
45-SML1160-25MG	25 mg	$380.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
InChI key	WIFPLULEUNBSTE-GZTJUZNOSA-N
Quality Level	100
SMILES string	O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).
Biochem/physiol Actions:	CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.
Biochem/physiol Actions:	CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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