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CD40-TRAF6 signaling inhibitor

SIGMA/SML1160 - ≥98% (HPLC)

Synonym: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one; Compound 6877002

CAS Number: 433249-94-6
Empirical Formula (Hill Notation): C17H17NO
Molecular Weight: 251.32
Linear Formula: C17H17NO
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1160-5MG 5 mg
 $105.00
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45-SML1160-25MG 25 mg
 $332.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
InChI key WIFPLULEUNBSTE-GZTJUZNOSA-N
Quality Level 100 
SMILES string O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).
Biochem/physiol Actions: CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.
Biochem/physiol Actions: CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40.
Biochem/physiol Actions: CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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