Synonym: 2-((6,7-Dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole; 6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-quinazoline; SKLB 1002
CAS Number: 1225451-84-2
Empirical Formula (Hill Notation): C13H12N4O2S2
Molecular Weight: 320.39
MDL Number: MFCD27938707
Linear Formula: C13H12N4O2S2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H,1-3H3 |
| InChI key |
RQVGFDBMONQTBC-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC1=NN=C(S1)SC2=C(C=C(OC)C(OC)=C3)C3=NC=N2 |
| solubility |
DMSO: 2 mg/mL, clear (warmed) |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
SKLB1002 is a cell permeable and potent VEGFR2 inhibitor that potently inhibits HUVEC cells proliferation, migration, invasion, and tube formation. It appears that SKLB1002 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase, focal adhesion kinase, and Src. SKLB1002 inhibits angiogenesis. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
