Salirasib
SIGMA/SML1166 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 162520-00-5
Empirical Formula (Hill Notation): C22H30O2S
Molecular Weight: 358.54
MDL Number: MFCD00467723
Linear Formula: C22H30O2S
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1166-10MG.
This image depicts SML1166-10MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C22H30O2S/c1-17(2)9-7- |
| InChI key | WUILNKCFCLNXOK-CFBAGHHKSA |
| Quality Level | 100  |
| SMILES string | O=C(O)C1=CC=CC=C1SC/C=C(C |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Salirasib has been used as a farnesyltransferase inhibitor. |
| Biochem/physiol Actions: | Salirasib (Farnesylthiosalicylic acid) is a RAS inhibitor that acts by dislodging the farnesylated protein from the membrane, facilitating Ras degradation. Salirasib impairs downstream signaling and suppresses growth and migration of proliferating tumor cells in in vitro and in vivo models. Salirasib (Farnesylthiosalicylic acid) has recently been shown to possess significant anti-inflammatory and anti-arthritic properties. |
| Biochem/physiol Actions: | Salirasib (Farnesylthiosalicylic acid) is a RAS inhibitor. |
| Biochem/physiol Actions: | Salirasib (S-trans,trans-Farnesylthiosalicylic Acid /FTS) is a synthetic small molecule that has an ability to block all forms of Ras, unlike farnesyltransferase inhibitors, which fail to inhibit K-Ras and N-Ras function due to alternative membrane-binding mechanisms. Salirasib along with gemcitabine, exhibits anti-tumor activity and biomarker modulation in preclinical models of metastatic pancreatic adenocarcinoma (PDA). It is also used as a potent therapeutic for lung cancer. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |