WZ4002

SIGMA/SML1168 - ≥98% (HPLC)

Synonym: N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide; WZ-4002

CAS Number: 1213269-23-8
Empirical Formula (Hill Notation): C₂₅H₂₇ClN₆O₃
Molecular Weight: 494.97
MDL Number: MFCD16621244
Linear Formula: C₂₅H₂₇ClN₆O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1168-5MG	5 mg	$74.10 1/EA	Add To Favorites
45-SML1168-25MG	25 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
InChI key	ITTRLTNMFYIYPA-UHFFFAOYSA-N
Quality Level	100
SMILES string	CN(CC1)CCN1C2=CC(OC)=C(NC3=NC=C(Cl)C(OC4=CC(NC(C=C)=O)=CC=C4)=N3)C=C2
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C

Biochem/physiol Actions:	WZ4002 is an irreversible inhibitor of the gatekeeper EGFR-T790M mutation that binds to the active conformation of the EGFR kinase forming a covalent bond with Cys 797.
Biochem/physiol Actions:	WZ4002 is effective in the treatment of lung adenocarcinomas due to EGFR (epidermal growth factor receptor) mutations.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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