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Pitstop 2

SIGMA/SML1169 - ≥98% (HPLC)

Synonym: N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide; Pitstop-2

CAS Number: 1332879-52-3
Empirical Formula (Hill Notation): C20H13BrN2O3S2
Molecular Weight: 473.36
Linear Formula: C20H13BrN2O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1169-5MG 5 mg
 $118.00
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45-SML1169-25MG 25 mg
 $475.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to light brown
form powder
Quality Level 100 
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Application: Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.
Biochem/physiol Actions: Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.
Biochem/physiol Actions: Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.
Biochem/physiol Actions: Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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