Pitstop 2
SIGMA/SML1169 - ≥98% (HPLC)
Synonym: N-
CAS Number: 1332879-52-3
Empirical Formula (Hill Notation): C20H13BrN2O3S2
Molecular Weight: 473.36
Linear Formula: C20H13BrN2O3S2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis. |
| Biochem/physiol Actions: | Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion. |
| Biochem/physiol Actions: | Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics. |
| Biochem/physiol Actions: | Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |