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SR2211

SIGMA/SML1170 - ≥98% (HPLC)

Synonym: 1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1-biphenyl]-4-yl)propan-2-ol; ;2-Fluoro-4′-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1′-biphenyl]-4-methanol; ML310

CAS Number: 1359164-11-6
Empirical Formula (Hill Notation): C26H24F7N3O
Molecular Weight: 527.48
Linear Formula: C26H24F7N3O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1170-5MG 5 mg
 $180.00
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45-SML1170-25MG 25 mg
 $722.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H24F7N3O/c27-23-15-21(24(37,25(28,29)30)26(31,32)33)5-6-22(23)20-3-1-18(2-4-20)16-35-11-13-36(14-12-35)17-19-7-9-34-10-8-19/h1-10,15,37H,11-14,16-17H2
InChI key KVHKWAZUPPBMLL-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)C(O)(C(F)(F)F)c1cc(c(cc1)c2ccc(cc2)CN3CCN(CC3)Cc4ccncc4)F
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: SR2211 (ML310) is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ).
Biochem/physiol Actions: SR2211 (ML310) is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORγ). RORγ is essential for interleukin 17 expression and differentiation of TH17 cells, important in autoimmune diseases including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and lupus. SR2211 (ML310) treatment of EL-4 murine T lymphocyte cells resulted in suppression of gene expression and production of IL-17 with an IC50 ~320 nM with no effect on the transcriptional activity of RORγ. In a mouse model of rheumatoid arthritis, SR2211 significantly reduced joint inflammation, suppressing inflammatory T cell function, expression and production of inflammatory cytokines, and macrophage activation.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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