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Lubiprostone

SIGMA/SML1173 - ≥98% (HPLC)

Synonym: (11a,15R)-11,15-Epoxy-16,16-difluoro-15-hydroxy-9-oxo-prostan-1-oic acid; Ru 0211; Spi 0211

CAS Number: 136790-76-6
Empirical Formula (Hill Notation): C20H32F2O5
Molecular Weight: 390.46
Linear Formula: C20H32F2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1173-10MG 10 mg
 $121.00
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45-SML1173-50MG 50 mg
 $489.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15+,17+,20+/m0/s1
InChI key WGFOBBZOWHGYQH-DKYLXPRQSA-N
Quality Level 100 
SMILES string FC(F)([C@@]1(O[C@H]2[C@@H]([C@@H](C(=O)C2)CCCCCCC(=O)O)CC1)O)CCCC
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: Lubiprostone helps to enhance intestinal permeability in humans. Hence it may inhibit leaky gut syndrome.
Biochem/physiol Actions: Lubiprostone is a bicyclic fatty acid that activates ClC-2 and CFTR chloride channels.
Biochem/physiol Actions: Lubiprostone is a bicyclic fatty acid that activates ClC-2 and CFTR chloride channels. Some reports suggest that lubiprostone opens CFTR or both CFTR and ClC-2 through interactions with the prostaglandin receptor EP4. Lubiprostone is used clinically to treat idiopathic chronic constipation and irritible bowel syndrome.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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