Synonym: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] cyclic (35)-disulfide; Depsipeptide; FK228; FR901228; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide
CAS Number: 128517-07-7
Empirical Formula (Hill Notation): C24H36N4O6S2
Molecular Weight: 540.70
MDL Number: MFCD18433404
Linear Formula: C24H36N4O6S2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1 |
| InChI key |
OHRURASPPZQGQM-GCCNXGTGSA-N |
| Quality Level |
100  |
| SMILES string |
O=C(N/C(C(N[C@@H](C(C)C)C(O[C@@]1([H])CC2=O)=O)=O)=CC)[C@@H](CSSCC/C=C/1)NC([C@H](N2)C(C)C)=O |
| solubility |
DMSO: 25 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2 that is converted to active form by glutathione. Romidepsin has IC50 values of 36 nM and 47 nM for HDAC1 and HDAC2, respectively. Romidepsin kills lymphoma cell lines overexpressing Bcl-2 and Bcl-XL, and has been approved for the treatment for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma, and a variety of other cancers. |
| Biochem/physiol Actions: |
Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2; antineoplastic. |
| Biochem/physiol Actions: |
Romidepsin promotes apoptosis, while hindering tumor growth in glioma models. |
| Packaging: |
1 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
