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WWL229

SIGMA/SML1180 - ≥98% (HPLC)

Synonym: 2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester; 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate

CAS Number: 1338575-28-2
Empirical Formula (Hill Notation): C16H22N2O5
Molecular Weight: 322.36
Linear Formula: C16H22N2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1180-5MG 5 mg
 $103.00
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45-SML1180-25MG 25 mg
 $404.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color colorless to light yellow
form oil
InChI 1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
InChI key XVBRVSAGMWRVCK-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
storage temp. 2-8°C
Biochem/physiol Actions: WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.
Biochem/physiol Actions: WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12161501

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