WWL229
SIGMA/SML1180 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 1338575-28-2
Empirical Formula (Hill Notation): C16H22N2O5
Molecular Weight: 322.36
Linear Formula: C16H22N2O5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | colorless to light yellow |
| form | oil |
| InChI | 1S/C16H22N2O5/c1-22-12-4- |
| InChI key | XVBRVSAGMWRVCK-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C(OC1=CC=C([N+]([O-])=O |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12161501 |