BMH-21
SIGMA/SML1183 - ≥98% (HPLC)
Synonym: N-
CAS Number: 896705-16-1
Empirical Formula (Hill Notation): C21H20N4O2
Molecular Weight: 360.41
MDL Number: MFCD27225377
Linear Formula: C21H20N4O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | faint yellow to dark orange |
| form | powder |
| InChI | 1S/C21H20N4O2/c1-24(2)11- |
| InChI key | BXYDVWIAGDJBEC-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C(N(C=CC=C1C(NCCN(C)C)= |
| solubility | DMSO: 1 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Application: | BMH-21 has been used in cell culture. |
| Biochem/physiol Actions: | BMH-21 has the ability to bind ribosomal DNA and prevent RNA polymerase I (Pol I) transcription and results in the disintegration of the nucleolus. It does not impair DNA damage detection. BMH-21 is considered as an important activator of the p53 pathway. |
| Biochem/physiol Actions: | BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines. |
| General description: | BMH-21 is a planar heterocyclic small molecule DNA intercalator. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |