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BMH-21

SIGMA/SML1183 - ≥98% (HPLC)

Synonym: N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

CAS Number: 896705-16-1
Empirical Formula (Hill Notation): C21H20N4O2
Molecular Weight: 360.41
MDL Number: MFCD27225377
Linear Formula: C21H20N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1183-5MG 5 mg
 $124.00
1/EA		 Add To Favorites
45-SML1183-25MG 25 mg
 $475.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color faint yellow to dark orange
form powder
InChI 1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)
InChI key BXYDVWIAGDJBEC-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(N(C=CC=C1C(NCCN(C)C)=O)C1=N2)C(C2=C3)=CC4=C3C=CC=C4
solubility DMSO: 1 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: BMH-21 has been used in cell culture.
Biochem/physiol Actions: BMH-21 has the ability to bind ribosomal DNA and prevent RNA polymerase I (Pol I) transcription and results in the disintegration of the nucleolus. It does not impair DNA damage detection. BMH-21 is considered as an important activator of the p53 pathway.
Biochem/physiol Actions: BMH-21 is a potent inhibitor of RNA Pol I.
Biochem/physiol Actions: BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.
General description: BMH-21 is a planar heterocyclic small molecule DNA intercalator.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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