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OF-1

SIGMA/SML1184 - ≥98% (HPLC)

Synonym: 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide

CAS Number: 919973-83-4
Empirical Formula (Hill Notation): C17H18BrN3O4S
Molecular Weight: 440.31
MDL Number: MFCD26964046
Linear Formula: C17H18BrN3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1184-5MG 5 mg
 $146.00
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45-SML1184-25MG 25 mg
 $0.00
1/EA
CALL FOR PRICE		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key YUNQZQREIHWDQT-UHFFFAOYSA-N
Quality Level 100 
SMILES string BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1  on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Features and Benefits: OF-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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