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GGTI-286 dihydrochloride

SIGMA/SML1186 - ≥90% (HPLC)

Synonym: (R)-N-[[5-[(2-Amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-L-lLeucine methyl ester dihydrochloride; GGTI 286 dihydrochloride; N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-leucine methyl ester dihydrochloride

CAS Number: 171744-11-9 (free base)
Empirical Formula (Hill Notation): C23H31N3O3S · 2HCl
Molecular Weight: 502.50
Linear Formula: C23H31N3O3S · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1186-5MG 5 mg
 $141.00
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45-SML1186-25MG 25 mg
 $830.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥90% (HPLC)
color white to light brown
form powder
InChI key IENQPUVVSDIXCT-UTKZUKDTSA-N
shipped in wet ice
SMILES string SC[C@H](N)CNc1cc(c(cc1)C(=O)N[C@@H](CC(C)C)C(=O)OC)c2ccccc2
solubility DMSO: 20 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) that selectively disrupts oncogenic K-Ras4B. New study shows that GGTI-286 reduces nuclear localization of β-catenin.
Biochem/physiol Actions: GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). CAAX peptidomimetic.
Other Notes: Air sensitive; dessicant.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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