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Vacquinol-1 dihydrochloride

SIGMA/SML1187 - ≥98% (HPLC)

Synonym: 2-(4-Chlorophenyl)-α−2-piperidinyl-4-quinolinemethanol dihydrochloride; NSC13316

CAS Number: 5428-80-8 (free base)
Empirical Formula (Hill Notation): C21H21ClN2O · 2HCl
Molecular Weight: 425.78
Linear Formula: C21H21ClN2O · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1187-5MG 5 mg
 $146.00
1/EA		 Add To Favorites
assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
InChI key VKLJPGAHSLIQKH-UHFFFAOYSA-N
Quality Level 100 
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Vacquinol-1 (NSC13316) is a brain penetrant inducer of catastrophic vacuolization in glioblastoma cells (GCs). Vacquinol-1 displays high cytotoxicity to GCs; it induces cell death by membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture of GCs. Vacquinol-1 originally was developed as an antimalarial compound.
Biochem/physiol Actions: Vacquinol-1 dihydrochloride is potentially used as a therapeutic for Glioblastoma multiforme (GBM). This drug is highly stable in vivo, with a half-life in plasma of 52 hour. Vacquinol-1 has high oral bioavailability and good brain penetration.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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