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PYZD-4409

SIGMA/SML1188 - ≥98% (HPLC)

Synonym: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione

CAS Number: 423148-78-1
Empirical Formula (Hill Notation): C14H7ClFN3O5
Molecular Weight: 351.67
MDL Number: MFCD01828668
Linear Formula: C14H7ClFN3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1188-5MG 5 mg
 $103.00
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assay ≥98% (HPLC)
color , white to very dark brown
form powder
InChI 1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H,(H,17,20)
InChI key MSYMKEYWUWVZQY-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC1=CC=C(N2C(C(C(N2)=O)=CC3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1 with an IC50 of 20 mM. PYZD-4409 induces cell death, and inhbits clonogenic growth of leukemia and myeloma cell lines, and inhibits leukemia xenograft tumor growth in mice.
Biochem/physiol Actions: PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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