SB290157 trifluoroacetate salt
SIGMA/SML1192 - ≥97% (HPLC)
Synonym: N2-
CAS Number: 1140525-25-2
Empirical Formula (Hill Notation): C22H28N4O4 · CF3CO2H
Molecular Weight: 526.51
Linear Formula: C22H28N4O4 · CF3CO2H
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C22H28N4O4.C2HF3O2/c23 |
InChI key | ZJRMPPVJAQWGEG-FYZYNONXSA |
optical activity | [α]/D +1.5 to +5°, c = 1.0 in DMSO |
Quality Level | 100 |
SMILES string | NC(NCCC[C@@H](C(O)=O)NC(C |
solubility | DMSO: 10 mg/mL, clear |
storage condition | desiccated |
storage temp. | −20°C |
Biochem/physiol Actions: | SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells, and has recently been found to be involved in nonimmunological roles in osteoblast differentiation, angiogenesis, and lipid metabolism. SB290157 is selective for C3aR over C5aR or other chemotactic GPCRs with an IC50 of 200 nM. It effectively blocks C3aR in humans, rat, guinea pig, and mouse.SB290157 was found to inhibit diet-induced obesity, metabolic dysfunction, and adipocyte signaling, in addition to inhibiting macrophage signaling. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |