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SB290157 trifluoroacetate salt

SIGMA/SML1192 - ≥97% (HPLC)

Synonym: N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt; SB 290157 trifluoroacetate salt

CAS Number: 1140525-25-2
Empirical Formula (Hill Notation): C22H28N4O4 · CF3CO2H
Molecular Weight: 526.51
Linear Formula: C22H28N4O4 · CF3CO2H
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1192-5MG 5 mg
 $111.00
1/EA		 Add To Favorites
45-SML1192-25MG 25 mg
 $414.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1
InChI key ZJRMPPVJAQWGEG-FYZYNONXSA-N
optical activity [α]/D +1.5 to +5°, c = 1.0 in DMSO
Quality Level 100 
SMILES string NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells, and has recently been found to be involved in nonimmunological roles in osteoblast differentiation, angiogenesis, and lipid metabolism. SB290157 is selective for C3aR over C5aR or other chemotactic GPCRs with an IC50 of 200 nM. It effectively blocks C3aR in humans, rat, guinea pig, and mouse.SB290157 was found to inhibit diet-induced obesity, metabolic dysfunction, and adipocyte signaling, in addition to inhibiting macrophage signaling.
Biochem/physiol Actions: SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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