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SU1498

SIGMA/SML1193 - ≥98% (HPLC)

Synonym: (2E)-2-Cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide; (E)-N-(3-Phenylpropyl)-cyano-3,5-diisopropyl-4-hydroxycinnamamide; AG-1498; SU 1498; Tyrphostin SU 1498; Tyrphostin SU1498

CAS Number: 168835-82-3
Empirical Formula (Hill Notation): C25H30N2O2
Molecular Weight: 390.52
Linear Formula: C25H30N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1193-5MG 5 mg
 $134.00
1/EA		 Add To Favorites
45-SML1193-25MG 25 mg
 $535.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChI key JANPYFTYAGTSIN-FYJGNVAPSA-N
Quality Level 100 
SMILES string N(CCCc2ccccc2)C(=O)C(=Cc1cc(c(c(c1)C(C)C)O)C(C)C)C#N
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.
Biochem/physiol Actions: SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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