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RO8191

SIGMA/SML1200 - ≥98% (HPLC)

Synonym: 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine; RO4948191

CAS Number: 691868-88-9
Empirical Formula (Hill Notation): C14H5F6N5O
Molecular Weight: 373.21
Linear Formula: C14H5F6N5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1200-25MG 25 mg
 $509.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI key GRHYZVJEXKTJOS-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1nc2[n]3c(nc(c3)c4nnc[o]4)ccc2c(c1)C(F)(F)F
solubility DMSO: 0.5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: RO8191 is a potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2).
Biochem/physiol Actions: RO8191 is an imidazonaphthyridine compound, which activates interferon (IFN) signals, IFN-stimulated genes (ISGs) expression and Janus kinase (JAK)/signal transducers and activators of transcription (STAT) phosphorylation.
Biochem/physiol Actions: RO8191 is an orally available, potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2). RO8191 suppresses HCV replication without inducing host cell toxicity.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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