RA-9
SIGMA/SML1206 - ≥98% (HPLC)
Synonym: (3E,5E)
CAS Number: 919091-63-7
Empirical Formula (Hill Notation): C19H15N3O5
Molecular Weight: 365.34
Linear Formula: C19H15N3O5
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H15N3O5/c23-19-15(9 |
InChI key | YUYPWAMLWZVHAE-KAVGSWPWSA |
Quality Level | 100 |
SMILES string | O=C(/C(CNC/1)=C/C2=CC=C([ |
solubility | DMSO: 2 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |