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RA-9

SIGMA/SML1206 - ≥98% (HPLC)

Synonym: (3E,5E)-3,5-Bis[(4-Nitrophenyl)methylene]-4-piperidinone

CAS Number: 919091-63-7
Empirical Formula (Hill Notation): C19H15N3O5
Molecular Weight: 365.34
Linear Formula: C19H15N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1206-5MG 5 mg
 $103.00
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45-SML1206-25MG 25 mg
 $404.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+
InChI key YUYPWAMLWZVHAE-KAVGSWPWSA-N
Quality Level 100 
SMILES string O=C(/C(CNC/1)=C/C2=CC=C([N+]([O-])=O)C=C2)C1=CC3=CC=C([N+]([O-])=O)C=C3
solubility DMSO: 2 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis.
Biochem/physiol Actions: RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB).
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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