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OICR-9429

SIGMA/SML1209 - ≥98% (HPLC)

Synonym: 6-Oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3′-morpholin-4-ylmethyl-biphenyl-3-yl]-amide

CAS Number: 1801787-56-3
Empirical Formula (Hill Notation): C29H32F3N5O3
Molecular Weight: 555.59
MDL Number: MFCD18364451
Linear Formula: C29H32F3N5O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1209-5MG 5 mg
 $196.00
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assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
InChI key GMCOGJQJFDQZCP-UHFFFAOYSA-N
Quality Level 100 
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429  on the Structural Genomics Consortium (SGC) website.

OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here .

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Features and Benefits: OICR-9429 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: OICR-9429 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the OICR-9429 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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