A66

SIGMA/SML1213 - ≥98% (HPLC)

Synonym: (2S)-N1-[2-(1,1-Dimethylethyl)-4′-methyl[4,5′-bithiazol]-2′-yl]-1,2-pyrrolidinedicarboxamide

CAS Number: 1166227-08-2
Empirical Formula (Hill Notation): C₁₇H₂₃N₅O₂S₂
Molecular Weight: 393.53
MDL Number: MFCD22378485
Linear Formula: C₁₇H₂₃N₅O₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1213-5MG	5 mg	$75.20 1/EA	Add To Favorites
45-SML1213-25MG	25 mg	$295.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H23N5O2S2/c1-9-12(10-8-25-14(20-10)17(2,3)4)26-15(19-9)21-16(24)22-7-5-6-11(22)13(18)23/h8,11H,5-7H2,1-4H3,(H2,18,23)(H,19,21,24)/t11-/m0/s1
InChI key	HBPXWEPKNBHKAX-NSHDSACASA-N
Quality Level	100
SMILES string	O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2
solubility	DMSO: 20 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α with an IC₅₀ of 32 nM and >100 fold selectivity for p110α over other class-I PI3K isoforms.
Biochem/physiol Actions:	A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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