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TG4-155

SIGMA/SML1217 - ≥98% (HPLC)

Synonym: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide

CAS Number: 1164462-05-8
Empirical Formula (Hill Notation): C23H26N2O4
Molecular Weight: 394.46
Linear Formula: C23H26N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1217-5MG 5 mg
 $103.00
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45-SML1217-25MG 25 mg
 $404.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H26N2O4/c1-16-13-18-7-5-6-8-19(18)25(16)12-11-24-22(26)10-9-17-14-20(27-2)23(29-4)21(15-17)28-3/h5-10,13-15H,11-12H2,1-4H3,(H,24,26)/b10-9+
InChI key YBHUXHFZLMFETJ-MDZDMXLPSA-N
Quality Level 100 
SMILES string [n]2(c3c(cc2C)cccc3)CCNC(=O)C=Cc1cc(c(c(c1)OC)OC)OC
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist.
Biochem/physiol Actions: TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist. TG4-155 has a 4730X selectivity over EP4 (2.4 nM vs 11.4 mM in binding assays), and a 7 fold selectivity over DP1 receptors. TG4-155 crosses the blood brain barrier, and has no antagonistic effects on EP4 signaling, and displays neuroprotective effects in a pilocarpine-induced status epilepticus (SE) seizure model. TG4-155 does not interfere with G-protein function or phosphodiesterase activity, and does not inhibit COX-1 or COX-2.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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