Pheophorbide-a
SIGMA/SML1218 - ≥90% (HPLC)
Synonym: pheophorbide a; (3S,4S,21R)
CAS Number: 15664-29-6
Empirical Formula (Hill Notation): C35H36N4O5
Molecular Weight: 592.68
MDL Number: MFCD00210345
Linear Formula: C35H36N4O5
Product Type: Chemical
assay | ≥90% (HPLC) |
color | blue, to dark brown to black |
form | powder |
InChI | 1S/C35H36N4O5/c1-8-19-15( |
InChI key | NSFSLUUZQIAOOX-QEWKCGBTSA |
SMILES string | O=C([C@@H]1C(OC)=O)C(C(N/ |
solubility | DMSO: 0.5 mg/mL, clear (warmed) |
storage condition | protect from light |
storage temp. | −20°C |
Application: | Pheophorbide-a has been used as a photosensitizer: • for the photodynamic therapy (PDT) in oral cancer cell lines • to test its effect on inducing oxidative stress and death in L. amazonensis • to test its effect on the viability of HeLa cells |
Biochem/physiol Actions: | Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype. |
Other Notes: | light sensitive |
Packaging: | 10, 50 mg in glass bottle |
RIDADR | NONH for all modes of transport |
Purity | ≥90% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12161501 |