Synonym: (4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
CAS Number: 364622-82-2
Empirical Formula (Hill Notation): C15H24N4O6S2 · H2O
Molecular Weight: 438.52
MDL Number: MFCD09749887
Linear Formula: C15H24N4O6S2 · H2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7-,8+,9+,10-,11-;/m1./s1 |
| InChI key |
NTUBEBXBDGKBTJ-WGLOMNHJSA-N |
| Quality Level |
100  |
| SMILES string |
[S](=O)(=O)(NC[C@H]1NC[C@H](C1)SC2=C(N3[C@H]([C@H]2C)[C@H](C3=O)[C@H](O)C)C(=O)O)N.O |
| solubility |
H2O: 5 mg/mL, clear (warmed) |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Doripenem hydrate is used to treat complicated urinary infection including Pyelonephritis caused by E.coli. Doripenem hydrate is promoted in the United States as DORIBAX®. This drug is synthesized from p-nitrobenzyl-protected enolphosphate 2b and N-(p-nitrobenzyloxycarbonyl)-protected aminomethylpyrrolidine. |
| Biochem/physiol Actions: |
Doripenem is an ultra-broad spectrum carbopenem antibiotic. |
| Biochem/physiol Actions: |
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria. |
| Legal Information: |
DORIBAX is a registered trademark of Shionogi Inc. |
| Packaging: |
10, 50 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
