Dutasteride

SIGMA/SML1221 - ≥98% (HPLC)

Synonym: 17β-N-[2,5-Bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5α-androst-1-en-3-one; (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide

CAS Number: 164656-23-9
Empirical Formula (Hill Notation): C₂₇H₃₀F₆N₂O₂
Molecular Weight: 528.53
MDL Number: MFCD00937869
Linear Formula: C₂₇H₃₀F₆N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1221-10MG	10 mg	$111.00 1/EA	Add To Favorites
45-SML1221-50MG	50 mg	$444.00 1/EA	Add To Favorites

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This image depicts SML1221-10MG.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
InChI key	JWJOTENAMICLJG-QWBYCMEYSA-N
optical activity	[α]/D +18 to +24°, c = 1 in chloroform-d
Quality Level	100
SMILES string	O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F)=O)([H])N1
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Dutasteride is a potent dual inhibitor of 5α-reductase isoenzymes types 1 and 2 (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride blocks testosterone conversion to dihydrotesterone, and is used clinically for treating benign prostatic hyperplasia (BPH).
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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