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Lopinavir

SIGMA/SML1222 - ≥98% (HPLC)

Synonym: (αS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-

CAS Number: 192725-17-0
Empirical Formula (Hill Notation): C37H48N4O5
Molecular Weight: 628.80
Linear Formula: C37H48N4O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1222-10MG 10 mg
 $31.70
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45-SML1222-50MG 50 mg
 $76.20
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
InChI key KJHKTHWMRKYKJE-SUGCFTRWSA-N
optical activity [α]/D -20 to -27°, c = 0.4 in methanol
Quality Level 100 
SMILES string N4(CCCNC4=O)[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@@H](NC(=O)COc3c(cccc3C)C)Cc2ccccc2)Cc1ccccc1
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Application: Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor.
Biochem/physiol Actions: Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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