Lopinavir
SIGMA/SML1222 - ≥98% (HPLC)
Synonym: (αS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-
CAS Number: 192725-17-0
Empirical Formula (Hill Notation): C37H48N4O5
Molecular Weight: 628.80
Linear Formula: C37H48N4O5
Product Type: Chemical
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This image depicts SML1222-50MG.
This image depicts SML1222-50MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C37H48N4O5/c1-25(2)34( |
| InChI key | KJHKTHWMRKYKJE-SUGCFTRWSA |
| optical activity | [α]/D -20 to -27°, c = 0.4 in methanol |
| Quality Level | 100  |
| SMILES string | N4(CCCNC4=O)[C@@H](C(C)C) |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor. |
| Biochem/physiol Actions: | Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24). |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |