XBD173
SIGMA/SML1223 - ≥98% (HPLC)
Synonym: AC-5216; Emapunil; N-
CAS Number: 226954-04-7
Empirical Formula (Hill Notation): C23H23N5O2
Molecular Weight: 401.46
MDL Number: MFCD07772312
Linear Formula: C23H23N5O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C23H23N5O2/c1-3-27(15- |
InChI key | NBMBIEOUVBHEBM-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | CN(C1=CN=C(C2=CC=CC=C2)N= |
solubility | DMSO: 2 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | XBD173 (emapunil, AC-5216) is a potent and selective translocator protein 18 kDa (TSPO) ligand with a Ki value of 0.297 nM. XBD173 acts at the TSPO translocator protein, formerly called the peripheral benzodiazepine receptor, which is involved in production of neuroactive steroids such as allopregnanolone in the brain. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. XBD173 enhances GABA-mediated neurotransmission via induction of neurosteroidogenesis and exhibits anti-anxiety and antidepressant-like effects. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |