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Torin2

SIGMA/SML1224 - ≥98% (HPLC)

Synonym: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

CAS Number: 1223001-51-1
Empirical Formula (Hill Notation): C24H15F3N4O
Molecular Weight: 432.40
Linear Formula: C24H15F3N4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1224-5MG 5 mg
 $150.00
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45-SML1224-25MG 25 mg
 $594.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
InChI key GUXXEUUYCAYESJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Torin2 has been used:
• to examine its effect on LC3B-II levels in BORCS5- KO cells
• to determine its potent activity (IC50 less than 1 μM) against A2780-cis ovarian cancer cells
• in western blot analysis
Biochem/physiol Actions: Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.
Biochem/physiol Actions: Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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