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Indisulam

SIGMA/SML1225 - ≥98% (HPLC)

Synonym: N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide; N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

CAS Number: 165668-41-7
Empirical Formula (Hill Notation): C14H12ClN3O4S2
Molecular Weight: 385.85
MDL Number: MFCD00945325
Linear Formula: C14H12ClN3O4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1225-5MG 5 mg
 $150.00
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45-SML1225-25MG 25 mg
 $594.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to pink
form powder
InChI 1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
InChI key SETFNECMODOHTO-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor.
Biochem/physiol Actions: Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.
Biochem/physiol Actions: Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319
Precautionary statements P302 + P352 - P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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