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YM-26734

SIGMA/SML1226 - ≥95% (HPLC)

Synonym: 1,1′-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis1-dodecanone

CAS Number: 144337-18-8
Empirical Formula (Hill Notation): C45H62O8
Molecular Weight: 730.97
MDL Number: MFCD00918068
Linear Formula: C45H62O8
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1226-5MG 5 mg
 $138.00
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This image depicts SML1226-5MG.

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3
InChI key CEJAYJCUSZHYDS-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC1=C(C2CC(C3=CC=C(O)C=C3)OC4=C2C=CC(O)=C4)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2.
Biochem/physiol Actions: YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC50 against rabbit platelet derived sPLA2 is 85 nM. YM-26734 is active against, but less potent for group I (pancreatic) sPLA2 (porcine pancreatic enzyme IC50 = 7 μM), and does not inhibit intracellular PLA2 isoforms.
Biochem/physiol Actions: YM-26734 is a natural product analog and a derivative of YM-26567-1, which is found in the fruit of Horsfieldia amygdaline. It exhibits a broad inhibitory spectrum towards different sPLA2s.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 41106300

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